![]() ![]() They act as potent antioxidants, potentially lowering your risk of heart disease, inflammation, and certain types of cancer ( 14, 15).īeet juice is also high in inorganic nitrates, which have been shown to increase athletic performance and decrease blood pressure and heart disease risk ( 16, 17, 18). What’s more, beets are a great source of betalains, which are pigments that give the vegetable its deep-red color. It’s relatively low in sugar, as most vegetables are naturally lower in sugar than fruits ( 13). One cup (240 ml) of beet juice provides ( 12): This colorful juice is made by blending beets and water. Choose low-sodium tomato juice whenever possible.īeet juice has gained popularity in recent years due to its associated health benefits. Furthermore, 1 cup (250 ml) provides almost twice your daily vitamin C needs. Tomato juice is very high in lycopene, which acts as an antioxidant and may lower your risk of heart disease. Considering that most people consume too much salt, try to select low-sodium options when possible ( 11). However, tomato juice can be very high in salt, a mineral that can increase blood pressure when consumed in excess. For example, one review linked increased intake of lycopene to a 13% lower risk of heart disease ( 10). Lycopene may lower your risk of heart disease and stroke. In fact, 80% of dietary lycopene is reported to come from tomato juice, spaghetti sauce, or pizza sauce ( 9). It’s also a good source of lycopene, a carotenoid and antioxidant that gives tomatoes their red color. Tomato juice is particularly high in vitamin C, a potent antioxidant that supports iron absorption and promotes skin and immune health ( 6, 7, 8). One cup (240 ml) of tomato juice provides ( 5): Still, many companies classify tomato juice as a vegetable juice due to its flavor and low sugar content. While many people consider the tomato to be a vegetable due to its culinary uses, it’s biologically a fruit. This appears to be the first report of a single dietary constituent clinically modulating drug transport.Tomato juice is not only a key ingredient in Bloody Marys but also enjoyed on its own as a delicious and healthy drink. Inherent OATP1A2 activity may be influenced by genetic factors. Naringin appears to have sufficient safety, specificity, and sensitivity to be a clinical OATP1A2 inhibitor probe. Inactivation of enteric CYP3A4 was probably not involved. Naringin most probably directly inhibited enteric OATP1A2 to decrease oral fexofenadine bioavailability. Individuals tested in both studies (n=9 of 12) had highly reproducible fexofenadine AUC with water (r(2)=0.85, P<0.001) and extent of reduction of it with grapefruit juice (r(2)=0.72, P<0.01). Fexofenadine AUCs with grapefruit juice and particulate fractions were 57% (P<0.001), 96% (not significant (NS)), and 97% (NS) of that with water, respectively. ![]() ![]() Fexofenadine area under the plasma drug concentration-time curves (AUCs) with grapefruit juice and naringin solution were 55% (P<0.001) and 75% (P<0.05) of that with water, respectively. Naringin and hesperidin's half-maximal inhibitions were 3.6 and 2.7 microM, respectively. In the other study, fexofenadine was administered with grapefruit juice, with or 2 h before aqueous suspension of the particulate fraction of juice containing known clinical inhibitors of enteric CYP3A4, but relatively low naringin concentration (34 microM), or with water. In one study, 120 mg of fexofenadine was ingested with 300 ml grapefruit juice, an aqueous solution of naringin at the same juice concentration (1,200 microM), or water. Two randomized, crossover, pharmacokinetic studies were performed clinically. Inhibition of OATP1A2 transport by flavonoids in grapefruit (naringin) and orange (hesperidin) was conducted in vitro. We showed previously that grapefruit and orange juices inhibited human enteric organic anion-transporting polypeptide (OATP)1A2 in vitro and lowered oral fexofenadine bioavailability clinically. ![]()
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